While working in his basement, Quinn Mallory opens the gateway to parallel worlds. For a test run, Quinn invites co-worker Wade Welles and his teacher, Professor Arturo, along. Upon opening the vortex, Quinn uses too much power, which causes the vortex to suck them in along with Rembrandt "Crying Man" Brown, who happened to be driving by Quinn's house. The four arrive on a world that experienced an ecological disaster and will have to survive until the timer hits zero.

After barely escaping the last world, the Sliders think they are home. But to their horror, Quinn and Arturo learn they are not and have instead arrived on a world where the Soviet Union rules America. Rembrandt has been arrested for trying to use American money and the only way to save him is for the others to help a group of revolutionaries rescue their imprisoned leader.

On a world where penicillin was never invented, Quinn is mistaken for his double, who is believed to be the cause of a massive epidemic. While he is imprisoned by a health agency, Wade shows signs of being infected and only Arturo can find the cure.

The Sliders arrive on a world that will be destroyed by an asteroid before they are due to slide. Arturo works with Bennish to develop an atom bomb to destroy the asteroid and Rembrandt gets caught up in an end of the world celebration, while Quinn and Wade confront their feelings for one another.

The Sliders arrive in the British States of America, where Arturo's double is plotting to assassinate a prince and take the throne. When the Sliders inadvertently foil the plot, they come into contact with a group of rebels trying to bring freedom to America.

The Sliders are separated on a world where the Hippie movement of the sixties is still alive and the US is at war with Australia. Wade and Rembrandt are mistaken for extraterrestrial prophets at a commune, while Quinn and Arturo race to fix a broken timer and rejoin the others.

On a world where being smart is the equivalent of being a sports star, Quinn is a popular college athlete and finds his double had underhanded dealings with gangsters. Meanwhile, Arturo discovers his late wife is alive on this world and tries for reconciliation after learning she is pressing for divorce.

The Sliders arrive on a world where roles are reversed with women holding the positions of power. Arturo becomes a candidate for the mayoral race in San Francisco, trying to bring about a "men's rights" movement.

Rembrandt has arrived on his dream world, where his double is as popular as Elvis, but has been dead for eight years. As Rembrandt gets to enjoy the fame he's long since wanted, an old enemy plots to make sure he disappears for good.

When the Sliders land on a seemingly ideal world, Wade wins the lottery. But Quinn discovers that the lottery is population control and the winners are killed.

After separating from Ryan and Henry the dog, the Sliders make a rough landing that reopens Quinn's bullet wound. On this world of mysticism and superstition, a witch doctor heals Quinn and has brains on the mind when they can't pay the bill. On the run from bounty hunters, the Sliders only hope is the mysterious Sorcerer, a man who could possibly get them home.

On a world where a biological weapon wiped out most of the male population, Quinn, Rembrandt and Arturo become objects of desire and are imprisoned by the government to be breeders. As they try to escape and regroup with Wade, they find there are others out to capture them.

A lightning bolt strikes the vortex during a slide, damaging the timer and trapping Quinn on the astral plane. Now the Sliders are stranded on a world with 1950s technology and Quinn can not be seen by the others. He tries to get the help from the only one who can see or hear him, a girl that has a history of hearing voices.

On a world where everything west of the Mississippi is part of the Nation of Texas, corporate lawyers carry gunslinging ways of the Old West. After Quinn gets mixed up in a showdown, he gains the reputation for fastest draw in San Francisco and tries to prevent the hostile takeover of a family-owned computer company.

While the Sliders wait to leave a world of violence, Quinn saves a woman named Michelle from her criminal boyfriend, Sid. Sid then goes after the Sliders through the vortex, where they all arrive on a world where San Francisco is a maximum security prison.

Wade witnesses a murder just before the slide, but as the Sliders land on the next world, the same murder is about to occur. This time, Wade intervenes and this gets the Sliders involved with a disgraced federal judge and a United States under martial law.

The Sliders land on a world where San Francisco is a national park dedicated to the preservation of dinosaurs, which is home to a deadly Allosaurus. A bad fall causes Arturo to injure himself and lose the timer. Quinn goes out alone to search for it, while the others hide out from the Allosaurus in a cave.

The Sliders have come to the most unexpected world of all... home. While Rembrandt and Wade use their sliding adventures to kickstart their careers, Arturo steals the timer and claims sliding as his invention. However, Quinn remains convinced they are not home.

Wade literally meets the man of her dreams, Derek Bond, on a world where ten percent of the population possess psychic abilities. It turns out Derek is a psychic and is next in line for the powerful position of Prime Oracle. But the future gets grim fast as Rembrandt and Arturo become prime suspects in a murder that hasn't happened yet.

On a world where Prohibition was never repealed, Rembrandt's double is famous for fighting crime and corruption. Unfortunately, the trouble starts when the Sliders land in the middle of a wedding, where the groom and bride are from mob organizations.

The Sliders arrive on a world where the young are in charge and Wade and Quinn's doubles were married corporate executives. Quinn winds up posing as his dead double and finds questions in his death. Meanwhile, Arturo and Rembrandt find themselves in trouble with the law and face jail time.

The Sliders land in the middle of a strange invasion and Quinn uses the timer to bring down one of the ships. Before barely escaping, the Sliders learn these new villains can slide at will and are soon captured on the next world. They learn their captors are the Kromaggs and are intent on conquering every parallel world.

The Sliders find themselves running into the same people on each new world, one of them being Quinn's former love, Daelin. After encounters on worlds where the Spanish rule America and Daelin is an abused wife, the Sliders arrive on a world where time moves backwards and they are accused of Daelin's murder. Quinn wants to save her, but it could have disastrous results.

In a San Francisco basement, physics post-graduate student Quinn Mallory has found a way to create portals to parallel universes. Inviting his physics professor Maximillian Arturo and his computer store colleague Wade Wells for a trip, a series of mishaps ropes in passing singer Rembrandt Brown and takes the Sliders off their planned route. Upon discovering a frozen world and one where Russia rules America, the quartet begins to doubt that they will be able to return to their own world anytime soon...

The sliders race to find the cure for a deadly plague that is consuming the inhabitants of that dimension.

The Sliders arrive in a world where an asteroid is about to collide with Earth and end all life. Unfortunately, they are stuck in this world for 72 hours. Professor Arturo may be the only one who can save them and this Earth.

Wade and Rembrandt are treated as gods when the sliders land on an Earth where free love still exists.

The Sliders land in a world where the American colonists lost the Revolutionary War and where the British States of America now stands. The Sheriff of San Francisco plots to assume power through the murder of the heir, Prince Harold III. Professor Arturo assumes the sheriff's identity to save Quinn from execution, thwart the dastardly deed and bring new ideas on democracy to the people.

In a world where intelligence takes precedence over athletics, Quinn replaces his double who is in hiding and competes as the captain of team in a sport named "Mindgame" which implements rugby-style activity with answering high caliber questions. Quinn discovers that his double was targeted by thugs who want him to throw the game to satisfy his gambling debts.

In a world where women dominate authority and traditional gender roles are reversed, Professor Arturo becomes the first male candidate for mayor. Although initially welcoming of the advances of a powerful woman, Rembrandt laments the manner in which he is tricked and used.

In a world where Rembrandt was the King of Rock N Roll and where impersonators show homage through his fashion sense, the Sliders must team up with his double to save him from a crazy and jealous former band member.

In a seemingly Utopian world where population control is a priority, citizens play the lottery at local ATM machines. The more they withdraw from the public account, the more chances they have to win the jackpot. Wade winds up a winner and now has to keep her end of the deal which makes the next slide all the more urgent. Rembrandt is arrested for trying to help a lottery winner reverse her fortunes.

In a dark world of mysticism and witchcraft imagery, Quinn finds he has a bounty on his head or to be specific, his brain which a witchdoctor selects as payment after running out on a medical bill. The Sliders seek the "Sorcerer" who promises to return them home if they help him.

In a world where the vast majority of men have succumbed to a deadly virus, the male Sliders find themselves arrested and put into service as breeders at a re-population center.

In a world where technology has been banned after the event at Hiroshima, the Sliders must find a way to fix the timer that was damaged by lightning. Quinn doesn't fully materialize and must accompany his friends in a ghost-like state in the astral plane as they run into the Bureau of Anti Technology whose real motive is to build up their technological cache.

In a world where San Francisco is part of the Republic of Texas and a combination of Western culture and technology exists along with saloons and office buildings, the Sliders find themselves in the middle of a hostile takeover attempt by corporate gunslingers who give the term "negotiate" a new meaning. Rembrandt finds himself at the exchange table where poker is played for corporate stock.

In a world where San Francisco serves as a prison, two new sliders join the regulars. One is a woman, Michelle, whom Quinn saved from a beating. The other is her savage boyfriend, Sid, who followed them. The Sliders are fitted with buddy bracelets which are used in a buddy system of justice. If one "buddy" commits a crime then the other is punished. Of course Quinn is responsible for Sid's predictable actions. The timer becomes a hot commodity for both prisoners and guards who want to escape an earthquake doomed city.

The Sliders land in a world where J. Edgar Hoover founded the nation and martial law has been in effect for 30 years. Chased by government officials, they must make a choice of whether to protect the last surviving copy of the Constitution which could sprout the idea of democracy or gain the release of a former judge who has some potential to be a new founding father.

In a world where San Francisco is a national park for the endangered dinosaurs, Professor Arturo stumbles and loses the timer. The Sliders are at the mercy of a poacher's whim if they want to survive but find assistance in a holographic park ranger.

After eighteen months, the sliders finally return home. However, all is not as it seems, particularly with Professor Arturo.

In a world where 10% of the population has psychic abilities, Rembrandt and Professor Arturo are arrested before a crime is committed. Wade falls for a man whom put himself in her dreams.

In a world where Bugsy Siegel succeeded in establishing a gambling empire in Northern California controlled by organized crime, Rembrandt and the others inadvertently disrupt the marriage of two families. Mistaken for the FBI Deputy Director and the Incorruptibles, Rembrandt leads a severely underfunded crime unit in a sting in order to save himself and his friends.

In a world with Howard Stern as president, adults over the age of thirty are treated as second class citizens who must then retire. Quinn fills in for his recently murdered double in an attempt to promote the EduLearn computer technology designed to replace human educators. However, he has seconds thoughts when he learns of this culture's desperate race to succeed before the mandatory retirement age. Arturo and Rembrandt handle curfew violations in a court of what is surely not their peers.

After accidentally shooting down a spacecraft, the Sliders are pursued between worlds by the eye-eating Kromaggs, in their first appearance, as this new enemy hunts and then interrogates them for their home coordinates while in prison on Earth 113.

In a world where San Francisco is part of the Republic of Nueva Espana, the Sliders are arrested by immigration police and sentenced to deportation to Canada. Quinn meets up with an old high school flame, Daelin, who helps in the escape despite a great loss to her. In the next world, Quinn sets her up with his double in Seattle after an abusive relationship. In the third world, they slide into a jail cell where they await trial for the murder of Daelin, an undercover policewoman. In this realm, clocks and blocks of time move backwards for them alone. Quinn learns that his attempts to save worlds are causing more harm than good.