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| Kate Beckinsale | Eliza Graves | |
| Jim Sturgess | Edward Newgate | |
| David Thewlis | Mickey Finn | |
| Brendan Gleeson | The Alienist | |
| Ben Kingsley | Silas Lamb | |
| Michael Caine | Benjamin Salt | |
| Jason Flemyng | Swanwick | |
| Sophie Kennedy Clark | Millie | |
| Sinéad Cusack | Mrs. Marian Pike | |
| Edmund Kingsley | Charles Graves | |
| Robert Hands | Elegant Lady | |
| Ciara Flynn | Farmer's Daughter | |
| Christopher Fulford | William Paxton | |
| Andrew Dallmeyer | Jeremiah | |
| Guillaume Delaunay | Arthur Timbs |
| Director |
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| Producer |
Mark Amin
René Besson |
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| Writer |
Joe Gangemi
Edgar Allan Poe |
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| Cinematography |
Thomas Yatsko
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| Musician |
John Debney
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An Oxford Medical School graduate takes a position at a mental institution and soon becomes obsessed with a female mental patient, but he has no idea of a recent and horrifying staffing change. |
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