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| Jake Gyllenhaal | Robert Graysmith | |
| Mark Ruffalo | Inspector David Toschi | |
| Anthony Edwards | Inspector William Armstrong | |
| Robert Downey Jr. | Paul Avery | |
| Brian Cox | Melvin Belli | |
| John Carroll Lynch | Arthur Leigh Allen | |
| Richmond Arquette | Zodiac 1 | |
| Bob Stephenson | Zodiac 3 | |
| John Lacy | Zodiac 4 | |
| Chloë Sevigny | Melanie | |
| Ed Setrakian | Al Hyman | |
| John Getz | Templeton Peck | |
| John Terry | Charles Thieriot | |
| Candy Clark | Carol Fisher | |
| Elias Koteas | Sgt. Jack Mulanax |
| Director |
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| Producer |
Cean Chaffin
Bradley J. Fischer |
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| Writer |
James Vanderbilt
Robert Graysmith |
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| Cinematography |
Harris Savides
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| Musician |
David Shire
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A San Francisco cartoonist becomes an amateur detective obsessed with tracking down the Zodiac killer. |
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